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A 2-year multicenter randomized double-blind placebo-controlled trial was carried out by Reljanovic et al

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This finding, taken with the available information on γ-ECS and GSH-S localization, leads to the view that the synthesis of γ-EC is restricted to the plastid but that GSH synthesis can also occur in the cytosol following γ-EC export across the plastid envelope (Wachter et al., 2005